Open access
Aug 2026
Impact of genetic polymorphisms on the response to transdermal fentanyl in cancer patients—a single-center, prospective, biological study
Background/objectives Transdermal fentanyl (TDF) is widely used for moderate-to-severe cancer pain, yet substantial variability in fentanyl exposure, analgesic response, and tolerability remains incompletely explained by clinical factors. We evaluated whether pharmacogenetic variability is associated with pharmacokinet...
Lucia Angelini, I. Azzali, A. Carlini et al.
· Frontiers in Pain Research · 0 citations