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Open access Sep 2026

Air Pollution Triggers Metabolomic Signature of Mitochondrial Dysfunction in Mice and Humans: Implications for Cardiovascular Disease Development

Background: Previous animal studies found that subchronic exposure to diesel exhaust (DE) induces hyperlipidemia, accompanied by upregulation of 12- and 15-lipoxygenase (LOX) pathways and hepatic mitochondrial dysfunction. However, the human relevance of these findings has not been established. Methods: We studied ApoE...

Yan Lin, Xing-Hua Qiu, Rajat Gupta et al. · 0 citations
Open access Aug 2026

Virus-induced deconjugation of ISG15 dysregulates innate immunity and cellular metabolism.

Genetically ablated the deISGylating activity of the SARS-CoV-2-encoded papain-like protease (PLpro) and found that loss of deISGylation boosted innate immune activation, attenuated viral replication, and promoted viral clearance in human cells and mice.

Jun-Ji Zhu, Guan-Qun Liu, Jie-Lin Xu et al. · 1 citation

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