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Author

O. Galal

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Jul 2026

Synergistic cardioprotection by liraglutide and deferoxamine against doxorubicin-induced cardiotoxicity via modulation of ACSL-4/Nrf-2/GPX-4 signaling.

It is demonstrated that simultaneous targeting of iron overload and antioxidant signaling confers enhanced cardioprotection against Dox-induced injury and the Lira-DFO combination may represent a promising adjunct strategy to mitigate anthracycline-associated cardiotoxicity.

Nada Monir, O. Galal, A. Awad et al. · 0 citations
Open access Aug 2026

Buspirone attenuates cyclophosphamide-induced renal dysfunction in association with alterations in miR-205/EGLN2, Nrf2, and PERK/ATF4/CHOP signaling

Buspirone pretreatment mitigated CPA-induced renal dysfunction, accompanied by increased miR-205 expression, reduced EGLN2 expression, enhanced Nrf2-associated antioxidant defenses, and attenuation of ER stress, inflammation, and apoptosis, thereby preserving renal function and tissue integrity.

Ahmed M. El-Dessouki, A. Alrashidi, Mohammad I Jumaa et al. · 1 citation

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