Human leukocyte antigen B*27 (HLA-B*27) is a major risk factor for autoimmune diseases such as axial spondyloarthritis (axSpA), acute anterior uveitis (AAU), and psoriatic arthritis (PsA). HLA-B*27 presents bacterial and self-antigens to disease-associated CD8+ T cells, however, how this leads to a pathogenic IL-17-med...
Pancreatic ductal adenocarcinoma (PDAC) is unresponsive to standard immunotherapies despite harboring cancer neoantigens capable of eliciting T cell responses. We completed two phase 1 clinical trials (NCT03956056 and NCT03122106) evaluating safety and immunogenicity of synthetic long peptide (SLP) and DNA personalized...
Felicia Zhang Perkins, Xiu-Li Zhang, Y. Yu et al.· Science Advances· 0 citations
This study comprehensively profiled relapsed SCLC samples along with patient-matched treatment-naive samples using whole-exome, whole-genome, and RNA-sequencing to describe the molecular landscape of relapsed SCLC to identify potential novel pathways for additional functional validation and eventually novel therapeutic...
Sid Devarakonda, My H. Hoang, S. Sankararaman et al.· Journal of Thoracic Oncology· 0 citations
Abstract Summary The druggable genome encompasses the genes that are known or predicted to interact with drugs. The Drug-Gene Interaction Database (DGIdb) provides an integrated resource for discovering and contextualizing these interactions, supporting a broad range of research and clinical applications. DGIdb is curr...
Lars Schimmelpfennig, M. Cannon, Quentin Cody et al.· Bioinformatics· 0 citations
The genomic variants that characterize MCL are explored and transcriptomic data is integrated to comprehensively describe MCL biology and demonstrate that diverse genomic lesions converge on common pathways involved in genomic instability, transcriptional regulation, and tumor survival.
Charlz Nithin Jerold, Brian V. Li, Matthew Mosior et al.· medRxiv· 0 citations
A framework for optimal personalized neoAg vaccination in B-lymphoma is defined and it is demonstrated that neoAg vaccines can safely synergize with CD8+ T cell-selective immunotherapies to prevent T-cell dysfunction and generate durable systemic anti-tumor immunity.
Yuang Song, E. Aladyeva, Ruan F. Vieira Medrano et al.· bioRxiv· 0 citations
TrioMix-UPD, an integrated short- and long-read sequencing framework for UPD detection and classification, is developed and established UPD as an underrecognized contributor to CHD.
Nahyun Kong, Javier Abello, Christopher J. Yoon et al.· Research Square· 0 citations
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