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Open access Aug 2026

Difluoromethoxy-Substituted Hexahydroquinolines as Multi-Target Anti-Inflammatory Agents: Mechanistic and Metabolomic Insights

Abstract In this study, a series of 15 difluoromethoxy-substituted hexahydroquinoline (HHQ) derivatives were synthesized and evaluated for their anti-inflammatory potential. The cytotoxicity profiles of the synthesized compounds were assessed using the MTT assay in LPS-stimulated RAW 264.7 macrophages. At 10 μM, severa...

Ezgi Pehlivanlar-Yavrucu, Ayca Aktas-Sukuroglu, Meryem Temiz-Resitoglu et al. · 0 citations
Open access Aug 2026

Plasma Metabolic Features Associated with Developmental Regression in Autism Spectrum Disorder: A Pilot Untargeted Metabolomics Study

Several plasma metabolic features showing abundance differences among children with REG+, REG−, and typically developing controls are identified and require confirmation using authenticated standards, targeted quantitative methods, and independently recruited cohorts before any diagnostic, predictive, or therapeutic re...

Cihan Aslan, O. Kaplan, N. Yalçın et al. · 0 citations

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