Lung cancer remains a leading cause of cancer-related mortality worldwide, and early diagnosis is critical for improving survival. However, early-stage malignancies can be subtle on chest X-rays, creating challenges for radiologists. This study evaluates Vision Transformers (ViTs) for predicting lung cancer one to two years before clinical diagnosis. We analyzed 259,361 chest X-rays from 91,020 imaging studies at the Jamaica Plains VA Hospital in Boston, MA. The dataset showed extreme class imbalance, approximately 1:150 cancer to non-cancer, which was addressed using hybrid under- and over-sampling and class-weighted loss optimization. Three ViT configurations were evaluated: a model trained from scratch, an ImageNet-pretrained model, and a Corona-pretrained model fine-tuned on the lung cancer dataset. Transfer learning improved performance, with pretrained models exceeding the scratch baseline by 6-10 percentage points in AUC and about 10-12 percent in balanced accuracy. ImageNet-pretrained models showed the most stable overall performance, while Corona-pretrained models achieved higher sensitivity in some settings but greater variability. Moderate resampling ratios, including 1:1 undersampling and 1.5:2 oversampling, provided favorable trade-offs between sensitivity, precision, and computational efficiency, reducing runtime by up to 70 percent without major performance loss. These findings demonstrate the potential of ViTs for early lung cancer risk prediction from routine chest X-rays. Although performance remains below clinical deployment thresholds, the results support further development of ViT-based triage systems to flag high-risk patients for earlier evaluation.
O. Kotevska, Ian Goethert, Michael McGee et al.· 0 citations
Large Language Models (LLMs) can memorize and reproduce sensitive, copyrighted, or otherwise undesirable training content, creating privacy, safety, and regulatory concerns. Machine unlearning offers a practical alternative to full retraining, but many existing methods apply broad or fixed parameter updates that can degrade utility and remain brittle under deployment changes such as post-training quantization, where forgotten knowledge may partially re-emerge. We propose Forgetting Only What Matters via Unlearning Layers (FOM-UL), a layer-level unlearning framework that selects transformer layers using a forget-to-retain significance score. This score identifies layers with high influence on the forget set and low sensitivity to the retain set, allowing FOM-UL to concentrate updates where they are most effective while leaving most of the model unchanged. This targeted update strategy improves the forgetting-utility trade-off and provides an empirical path toward quantization-resilient unlearning by reducing the chance that small, diffuse updates are erased by low-bit rounding. Across TOFU, KnowUnDo, and MUSE-style evaluations, FOM-UL reduces residual memorization compared with strong GA, NPO, KLD, SURE, ReLearn, and LUNAR-based baselines while preserving retain-set utility close to the vanilla model. Under 8-bit and 4-bit post-training quantization, FOM-UL maintains stronger memorization suppression and utility preservation than competing methods, and adversarial prompt evaluations show lower recovery of forgotten content. Overall, FOM-UL provides an efficient unlearning strategy that improves targeted forgetting, utility preservation, and deployment robustness without claiming formal guarantees of erasure.
Ravi Ranjan, O. Kotevska, Agoritsa Polyzou· 0 citations
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