Cardiovascular risk assessment based on traditional risk factors may not fully capture subclinical vascular injury and vascular aging, supporting interest in biomarkers reflecting underlying vascular mechanisms. Endothelial dysfunction, altered methylarginine metabolism, and chronic low-grade inflammation represent int...
A. Melnitskaia, L. Machekhina, V. Pykhtina et al.· Frontiers in Cardiovascular...· 0 citations
Atherosclerosis is an age-related immune-metabolic disease in which lipid retention, endothelial dysfunction, innate immune activation, and vascular remodeling interact over decades. In older adults, inflammaging, mitochondrial dysfunction, defective autophagy/mitophagy, and cellular senescence may lower the threshold...
Yelizaveta A. Marakhovskaya, Ksenia A. Eruslanova, O. Maltseva et al.· Biomolecules· 0 citations
Advances in understanding mitochondrial biology have enabled the development of novel therapeutic approaches, including activators of the PINK1/Parkin pathway, inhibitors of LRRK2 and α-synuclein aggregation, and strategies promoting mitochondrial biogenesis and intercellular transfer, offering potential for disease mo...
A. V. Poznyak, V. Pavshintsev, Aleksandra O. Utkina et al.· International journal of inn...· 0 citations
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