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Open access Aug 2026

Therapeutic Modulatory Effect of Irvingia wombolu Leaf Fractions in Managing Inflammation and Oxidative Stress

Background: This study investigated the anti-inflammatory and antioxidant activities of leaf fractions and their effects on selected biochemical indices. Methods: A crude ethanolic leaf extract was partitioned using n-hexane, ethyl acetate, and ethanol. Phytochemical constituents were assessed qualitatively and quantit...

O. M. Onyia, I. Okoro, C. E. Onyia et al. · 0 citations
Sep 2026

Integration of network pharmacology, structure-based pharmacophore modeling, DFT, molecular docking, and molecular dynamics simulations to identify multi-target small molecule inhibitors against Alzheimer's disease.

The findings of this study suggest that Hit1 could be a promising multi-target molecule capable of modulating cholinergic transmission, neuronal survival pathways, and oxidative stress in AD.

D. O. Onwu, R. Oria, Y. A. Adekunle et al. · 0 citations

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