Author

O. Ohara

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Open access Jul 2026

Enrichment-free deep proteomics enables proteome-scale analysis of methionine oxidation

Abstract Advances in mass spectrometry (MS)-based proteomics have enabled the large-scale characterization of posttranslational modifications (PTMs) through affinity-based enrichment. However, this technique introduces a bias towards selectively enrichable modifications, thus leaving oxidative modifications underexplor...

Hiromasa Mitsui, Yusei Okuda, R. Konno et al. · DNA Research · 0 citations

Open access Aug 2026

Disruption of de novo fatty acid biosynthesis rewires cellular lipid metabolism toward mTOR-associated compensatory fatty acid uptake

Integrative multi-omics analyses in EL4 T cells reveal unrecognized mechanisms of lipid metabolic adaptation and highlight a regulatory network that coordinates fatty acid uptake in response to impaired lipid synthesis.

Takeru Endo, T. Kanno, R. Konno et al. · Scientific Reports · 0 citations