PURPOSE OF REVIEW
This review highlights the rationale for and clinical experience in advancing age-specific adjuvantation systems to develop well tolerated and effective pediatric HIV vaccines.
RECENT FINDINGS
Due to both cellular and soluble factors, infant immunity is distinct from that of older children and adult...
K. Smolen, K. De Paris, Asimenia Angelidou et al.· Current Opinion in HIV and A...· 0 citations
Chronic viral infections are ubiquitous in humans, with individuals carrying multiple viruses that can reactivate during physiological stress, including severe illness1. Notably, SARS-CoV-2 infection has been shown to reactivate chronic viruses such as Epstein–Barr virus and cytomegalovirus, yet the full extent, tempor...
Cole P. Maguire, Jing Chen, Nadine Rouphael et al.· Nature· 3 citations
Understanding vaccine durability is key to designing immunizations with long-term efficacy. Leveraging the Immune Signatures Data Resource, a compendium of transcriptomic and immunological responses from 1405 healthy adults (18+ years) across 24 vaccines, we investigated shared immune mechanisms underlying durabl...
Marco Sanna, Jing Chen, Paolo Palma et al.· Journal of Immunology· 0 citations
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