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Oliver Fiehn

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Open access Aug 2026

Using Hydrogen/Deuterium Exchange in Untargeted LC-MS Analysis of Small Molecules

Liquid chromatography–hydrogen/deuterium exchange–mass spectrometry (LC-HDX-MS) provides orthogonal structural information that complements conventional LC-MS and improves confidence in small-molecule structural elucidation. Although HDX-MS is well established in protein research, its application to small molecules rem...

Tomáš Čajka, J. Hricko, Lucie Rudl Kulhavá et al. · 0 citations
Preprint Oct 2026

Integrated omics reveals actionable drivers of bioactive variation in US milk

Despite milk being a global dietary staple, the molecular basis of its health-relevant bioactivity and the factors governing fine-scale compositional variation remain poorly understood. Here, we present an integrated seven-layer omics characterization of 60 US retail milk samples from ten geographic regions, combining...

Cheng-En Tan, M. Barboza, Pagkratios Tagkopoulos et al. · 0 citations
Open access Aug 2026

Plasma as Proxy for Tissue Metabolism When Extending Lifespan in Mice

Overall, plasma can only serve as limited proxy for tissue metabolism, and several potential blood biomarkers were discovered as concordant in plasma and tissues in lifespan-extending interventions.

Sara Greenfield, C. Brown, Oliver Fiehn · 0 citations

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