Olivia A Fraser

Multisite Threonine Phosphorylation in the SPT5 C‑Terminal Region 1 Enables Sequence-Dependent Regulation without Global Structural Remodeling

Phosphorylation of intrinsically disordered regions (IDRs) is widely viewed as a mechanism for encoding regulatory information through structural transitions, as exemplified by the RNA polymerase II C-terminal domain (CTD), where phosphorylation induces local conformational changes such as proline isomerization. Howeve...