Thiooxazole Formation on a Nontypeable Haemophilus influenzae Virulence Factor Requires a Mixed-Valent Diiron Cofactor
The multinuclear nonheme iron-dependent oxidative enzyme (MNIO) family employs a multi-iron cofactor to catalyze a range of post-translational modifications (PTMs) in the biosynthesis of ribosomally synthesized, post-translationally modified peptide (RiPP) natural products. While significant progress has been made towa...