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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Olivia M. Swanson

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Open access Sep 2026

Antigenic and structural analysis of the influenza hemagglutinin lateral patch

ABSTRACT The lateral patch epitope of the H1 hemagglutinin (HA) was a dominant target of antibodies following exposure to the 2009 pandemic H1N1 virus. However, the conservation and mechanisms of antigenic drift in the lateral patch remain unresolved. Here, we used lateral patch-specific monoclonal antibodies (mAbs) to...

Jordan I. Lemus-Reyes, Monica L. Fernández-Quintero, Edgardo Ayala et al. · 0 citations
Jul 2026

Evaluating AlphaFold 3 immune complex structure prediction and cryo-EM analysis of broadly neutralizing antibodies towards influenza hemagglutinin 2309571

Evaluated the accuracy of AlphaFold 3 (AF3) in predicting immune complexes of a known class of bnAbs towards a conserved epitope on influenza hemagglutinin (HA) and resolved atomistic details with high-resolution SPA cryo-EM that explain challenges with AF3 immune complex prediction.

Morgan Gee, Pragati Sharma, Alesandra J. Rodriguez et al. · 0 citations
Open access Aug 2026

A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability.

The AIntibody challenge shows that AI can optimize antibodies in defined, biologically grounded regimes, in addition to highlighting critical gaps including affinity prediction and library-inspired antibody design and cross-task generalization.

M. Erasmus, Daniel Bedinger, Elizabeth Hopkins et al. · 0 citations

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