Sep 2026
The early RNA decay factor ZC3H18 directs first intron splicing.
Pre-mRNA splicing is essential for gene expression. In human cells, the cap-binding complex (CBC) has long been known to facilitate first intron splicing, but it is by an unknown mechanism. The CBC also promotes early RNA decay by recruiting the nuclear exosome targeting (NEXT) complex via the linker proteins ARS2 and...
Marion Le Rest, Nour el Houda Benbahouche, Christopher C. Kuhn et al.
· Molecules and Cells · 0 citations