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Author

Omar Hadieh

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Review Open access Sep 2026

Synthetic aminoglycoside derivatives as anti-virulence agents against multidrug-resistant Acinetobacter baumannii

Acinetobacter baumannii presents a severe clinical challenge in critical care due to its rapid acquisition of drug resistance and its ability to form dense biofilms on medical equipment. While traditional antibiotic research focuses almost exclusively on essential bacterial viability targets, targeting virulence factor...

N. S. Faris, Omar Hadieh, Mohammad M. Hadieh · 0 citations
Open access Sep 2026

Structural Prerequisites for Pim-1 Kinase Inhibition and the Identification of a Pyrazolyl-Methylene-Indolinone Hit

Introduction Pim-1 is a serine/threonine kinase of the pan-Pim family (Pim-1, −2, and −3), whose overexpression is associated with various cancers. Its distinctive hinge-region architecture provides opportunities for selective inhibitor development, with several inhibitors reported as clinical candidates. Understanding...

Rufaida Al Zoubi, Omar Hadieh, Soraya Alnabulsi et al. · 0 citations

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