Review
Oct 2026
Caloric restriction mimetics rewire the AMPK-mTOR-ULK1 signaling nexus to restore autophagic proteostasis in the aging brain.
Brain aging is driven by progressive failure of neuronal proteostasis, culminating in the accumulation of toxic protein aggregates characteristic of Alzheimer's, Parkinson's, and Huntington's diseases. The AMPK-mTOR-autophagy signaling hub integrates cellular energy status with protein clearance machinery, making it a...
H. Al-Jehani, Hayder M. Al-kuraishy, Ahmed M. Abdelaziz et al.
· Molecular and cellular neuro... · 0 citations