Detection-Guided ROI-Constrained Diffusion for Weakly Supervised White Blood Cell Segmentation: A Retrospective Internal and External Dataset Evaluation
Background: Accurate white blood cell (WBC) segmentation is important for quantitative microscopic image analysis, but conventional supervised approaches depend on labor-intensive pixel-level annotations and may exhibit reduced robustness across datasets. This study proposes a detector-guided, region of interest (ROI)-...