Oriana Arias-Valderrama

Clinical evidence on non-viral CAR-T cell therapies for solid tumors: a scoping review

Background Chimeric antigen receptor (CAR) T-cell therapy in solid tumors is hindered by the immunosuppressive tumor microenvironment and by toxicities associated with viral-vector manufacturing. Non-viral gene delivery platforms have emerged as a potential alternative, though clinical evidence remains fragmented. Meth...