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Owen Byford

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Open access Oct 2026

The proteasome and ERAD pathways can regulate hepatitis E virus pORF1 proteostasis and genome replication

Hepatitis E virus (HEV) is a major cause of acute viral hepatitis, with an estimated 20 million human infections annually. Its diverse host range presents a significant zoonotic threat, yet the molecular mechanisms underpinning HEV–host interactions remain poorly characterised. Here, we used transposon-based insertion...

Khadijah M. Abualsaoud, Frazer J. T. Buchanan, Owen Byford et al. · 0 citations
Open access Sep 2026

Integrative structure of norovirus NS3 suggests a role in RNA transport

A full-length, membrane-associated model supports a role for NS3 as a candidate membrane-spanning RNA translocase that may couple ATP hydrolysis to genome movement and establishes a basis for mechanistic studies and structure-guided antiviral design.

Meryl Haas, T. Hoeksma, J. Mills et al. · 0 citations

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