Author

P. A. Sánchez‐Murcia

3 papers indexed here

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Open access Aug 2026

Conformational switching of Trp399 regulates opening and closing of loop-1 in galactofuranosyl transferase 2 of Mycobacterium tuberculosis.

Mycobacterial cell-wall assembly depends on multiple glycosyltransferases among which the processive galactofuranosyl transferase 2 (GlfT2) executes alternating β(1 → 5) and β(1 → 6) transfers of galactofuranose (Galf) within a single catalytic site through an oxocarbenium-like transition state. Despite the well charac...

Yasir Ali, P. A. Sánchez‐Murcia, S. Kozmon · International Journal of Bio... · 0 citations

Open access Aug 2026

A supramolecular complex of palmitoylated Orai C-terminal peptide and cyclodextrin targets the plasma membrane to reduce store-operated calcium channel activity

Palmitoylation is a widely employed strategy for anchoring peptides to lipid membranes, but it can also lead to uncontrolled self-assembly. The lipid moieties can promote clustering into heterodispersed aggregates that distribute unevenly, thereby reducing accessibility and inducing undesired uptake mechanisms that lim...

Juan Toledo-Marcos, Bruno Di Geronimo, Sanja Curcic et al. · Materials Advances · 0 citations

Open access Sep 2026

GH172 Difructose Dianhydride I Synthase: A Two-Stepped Journey via Glycosylation and Cyclization Using QM/MM Metadynamics.

The difructose dianhydride I synthase/hydrolase α FFase 1 catalyzes the reversible transformation of inulobiose into difructose dianhydride I, a component of caramel. The proposed reaction mechanism of such a transformation consists of a glycosylation step followed by a cyclization to yield the dianhydride from the dis...

Santiago Alonso-Gil, Bruno Di Geronimo, T. Kashima et al. · Chemistry · 0 citations