Sickle cell trait (SCT) is increasingly recognized as a risk factor for adverse health outcomes. We utilized three large US electronic health record-based biobanks (Vanderbilt University Medical Center’s BioVU, Penn Medicine Biobank, and All of Us) to conduct phenome-wide association (PheWAS) and clinical laboratory-wi...
M. Hysong, Megan M. Shuey, T. Miller-Fleming et al.· American Journal of Human Ge...· 0 citations
Summary Chronic, low-grade systemic inflammation is a polygenic trait captured with the INFLA-score, a composite of C-reactive protein, platelet count, leukocyte count, and granulocyte-to-lymphocyte ratio. We derived a polygenic risk score from the INFLA-score (iPRS) in a multi-ancestry population from the UK Biobank (...
H. Jandu, Ayo Olowofela, Megan M. Shuey et al.· HGG advances· 0 citations
An advanced review of inference techniques for NVRVs, with technical expositions focusing on the problem of measuring and testing network change in dynamic and heterogeneous settings, and reviews approaches for modeling networks as both responses and covariates.
A. Roy, P. Auer, Anjishnu Banerjee· WIREs Computational Statisti...· 0 citations
This work fine-mapped UK Biobank-derived genome-wide association study (GWAS) signals from 164 traits and identified e/sQTL colocalizations for 10,611 GWAS signals, including 7096 that colocalize with secondary e/sQTLs.
Peter Orchard, T. Blackwell, L. Kachuri et al.· Science· 0 citations
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