P. B. da Silva

Cafestol and kahweol: coffee diterpenes with trypanocidal activity and cardioprotective effects

Introduction Chagas disease (CD), caused by Trypanosoma cruzi, remains a major public health challenge in Latin America, affecting more than 7 million people worldwide and approximately 100 million individuals at risk of infection. Current chemotherapy relies exclusively on benznidazole and nifurtimox, which present si...