ADAM17, also known as tumor necrosis factor-converting enzyme (TACE), is a pleiotropic protease that contributes to inflammation and cancer progression by activating epidermal growth factor receptor (EGFR) signaling and IL-6 trans-signaling, among other pathways. Because ADAM17 signaling remains poorly characteri...
André Luz, Joana Santos, J. Catarino et al.· BMC Cancer· 0 citations
Colorectal cancer (CRC) remains a major global health burden, with approximately 2 million new cases and 1 million deaths annually. The growing resistance to conventional chemotherapy highlights the need for new therapeutic strategies against drug-resistant CRC. In this study, platinum(II) complexes of the general fo...
A. Maroń, Sandra Cordeiro, C. Marques et al.· Journal of Medicinal Chemist...· 0 citations
IL1RN rs4251961 may represent a novel genetic marker for PD, with clinical relevance given its inflammatory role and therapeutic use of recombinant IL-1RA in chronic inflammatory diseases, and supports validation in larger European cohorts.
Joana Couceiro, Carlos Família, J. Brito et al.· International Journal of Mol...· 0 citations
A one‐pot synthesis of aromatic aminopropyl lactams (ArAPLs) via hydrolysis of bicyclic amidines (DBN, DBU), followed by reductive amination with aromatic aldehydes supports the cytotoxic potential of ArAPLs.
M. Martins, Ruben Valente, Ruben Amaro et al.· ChemMedChem· 0 citations
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