Cardiovascular-kidney-metabolic (CKM) syndrome is a systemic disorder defined by the overlapping burden of heart failure (HF), chronic kidney disease (CKD), diabetes, and obesity. Although sex differences in cardiovascular disease are increasingly recognized, sex-specific patterns of mortality and renal progressi...
D. Hochstein, R. Loutati, V. Copeland et al.· European Heart Journal· 0 citations
Patients with advanced chronic kidney disease (CKD) and heart failure (HF) are systematically underrepresented in clinical trials despite comprising a substantial proportion of real-world HF populations [1]. Whether contemporary care has translated into improved outcomes in this high-risk group particularly among...
D. Hochstein, D. Sternik, V. Copeland et al.· European Heart Journal· 0 citations
In patients with late-stage metabolic syndrome, CKD identifies a high-risk subgroup with a graded increase in mortality and dialysis risk compared with eGFR ≥60, and the heightened dialysis risk remained pronounced after accounting for competing death.
D. Hochstein, R. Loutati, V. Copeland et al.· European Heart Journal· 0 citations
This analysis revealed unrecognized plasticity, showing that cell fate established during early patterning can be later revised and provides a potential mechanism for how cell fate is robustly established in complex patterned tissues.
Jonathan Levinsohn, Samuel Grindel, Bernhard Dumoulin et al.· Nature Genetics· 2 citations
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