Author

P. Brzdąk

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Open access Sep 2026

Pathogenic NLGN4X variants reveal dual roles in synaptic connectivity and cortical development

Neuroligins are synaptic adhesion molecules important for neurodevelopment, and rare, highly penetrant variants underlie neurodevelopmental disorders (NDDs). Here, we characterize a rare missense variant NLGN4X G243R identified in a pedigree with NDDs and associated with severe protein trafficking deficits. NLGN4X G2...

E. Hong, Miriam Reyes Mendez, C. Guissart et al. · Translational Psychiatry · 0 citations

Open access Jul 2026

Dopamine D2-like receptors differentially shape GABAergic plasticity in distinct subtypes of hippocampal VIP interneurons.

Dopamine regulates diverse brain functions, including learning and memory, primarily through two receptor types, D1R and D2R, which activate and inhibit adenylate cyclase, respectively. Dopaminergic system critically modulates glutamatergic transmission, but less is known about its impact on GABAergic plasticity, in wh...

K. Lebida, P. Brzdąk, Patrycja Droździel et al. · Scientific Reports · 0 citations