Quantification of retinal ganglion cell (RGC) loss provides a sensitive and reproducible measure of neurodegeneration in mouse models of neurological disease and injury. In experimental autoimmune encephalomyelitis (EAE), a widely used mouse model of multiple sclerosis, inflammation of the optic nerve can lead to opti...
Jackson W. Mace, P. Calabresi, Marjan Gharagozloo· Journal of Visualized Experi...· 0 citations
Using single-nucleus RNA-sequencing analysis of RGCs from donors with MS and control individuals, it is found that CFH expression was strongly correlated with intrinsic resilience to RGC degeneration and reveals a non-canonical intracellular function of CFH in neurons.
Christina Mayer, Marcel S. Woo, J. Sonner et al.· Nature· 0 citations
Inhibitory neurons emerged as a key target cell type for MS-associated variants, with seven loci, including STAT3, displaying altered expression only in these cells, suggesting that MS susceptibility may reflect reduced central nervous system resilience to inflammatory challenges.
Lu Zeng, Atlas Khan, Kathryn C. Fitzgerald et al.· Nature Genetics· 0 citations
It is shown that inflammation reprograms OPC lipid metabolism, linking altered metabolism to remyelination failure and highlighting LXR activation as a therapeutic approach to enhance remyelination in multiple sclerosis.
Judy J Lee, Matthew D. Smith, Xiaojing Deng et al.· bioRxiv· 0 citations
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