Mitochondria integrate bioenergetics, redox signalling, calcium handling, biosynthesis, apoptosis, and stress responses. Their contribution to ageing depends less on any single pathway than on the ability to sustain these functions through continuous maintenance, remodelling, and inter-organelle communication. This rev...
P. Chmielewski· Biogerontology (Dordrecht)· 0 citations
Biological aging is accompanied by persistent tissue-damage signaling, chronic inflammation, extracellular matrix remodeling, cellular senescence, and declining regenerative capacity. Taken together, these features resemble an injury response that is repeatedly initiated but fails to progress reliably through clearance...
P. Chmielewski, Bartłomiej Strzelec· International Journal of Mol...· 0 citations
This work evaluates the mechanistic and translational evidence for all twelve hallmarks of aging framework and examines RNA-processing defects and extracellular matrix remodeling as candidate processes without classifying either as an additional hallmark.
P. Chmielewski, Bartłomiej Strzelec· International Journal of Mol...· 0 citations
This narrative review examines AD mechanisms, biomarkers, and therapeutic prospects from a geroscience perspective and applies the eight hallmarks of neurodegenerative diseases as an analytical framework to establish which preventive strategies and biomarker-guided, stage-matched combination therapies improve clinicall...
Improved molecular, spatial and functional resolution of senescent states will be essential for developing biomarker-guided and tissue-specific interventions that preserve the beneficial functions of transient senescence while limiting its chronic deleterious effects.
P. Chmielewski· Biogerontology (Dordrecht)· 1 citation
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