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Author

P. Cramer

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2 papers indexed here

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Open access Aug 2026

Oriented binding of transcription factors to nucleosomes remodels chromatin at human promoters.

Transcription factors (TFs) can access nucleosomes via five distinct modes: gyre-spanning, periodic-binding, dyad-binding, and end-binding modes as well as an oriented binding mode, where the TF binding motif shows orientational preference relative to the nucleosome. Here, we report the first structure of an oriented T...

Tianyi Xiao, C. Crowe-McAuliffe, M. Ochmann et al. · 0 citations
Open access Jul 2026

Transcription initiation drives dosage compensation establishment and maintenance in male Drosophila

Dosage compensation (DC) in Drosophila equalizes X chromosome–linked gene expression via the male-specific lethal complex, which acetylates histone 4 lysine-16 on the male X chromosome. How DC is established during early embryogenesis remains obscure, largely due to the difficulty of obtaining sufficient sex-specific m...

Ronald Oellers, A. Alexiadis, Yidan Sun et al. · 0 citations

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