Beyond classical electrostatic screening: Non-specific binding of adenosine triphosphate drives long-range protein repulsion.
Overcharging of proteins by multivalent phosphate anions, such as adenosine triphosphate (ATP) and tripolyphosphate (TPP), can strongly modulate protein-protein interactions and colloidal stability, yet its physical origin and consequences remain incompletely understood. Here we examine how ATP and sodium tripolyphosph...