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Author

P. De Jager

2 papers indexed here

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Open access Sep 2026

BAG3 coordinates astrocytic proteostasis of Alzheimer's disease-linked proteins via proteasome, autophagy, and retromer interactions.

Bcl-2-associated athanogene 3 (BAG3) is a mediator of chaperone-assisted selective autophagy, and in the brain, is most highly expressed in astrocytes. However, its role in astrocytes remains poorly defined. Given the genetic and pathological links of BAG3 to proteostasis and neurodegenerative diseases, we investigated...

Zachary M. Augur, Garrett M. Fogo, Courtney R. Benoit et al. · 0 citations
Open access Sep 2026

Rest-activity and circadian rhythm parameters relate to cognition and disability outcomes in multiple sclerosis

OBJECTIVE: To prioritize novel measures of disease progression, we examined whether actigraphy-derived rest-activity rhythm (RAR) parameters relate to cognitive performance as well as disability in a multiple sclerosis (MS) cohort enrolled in a prospective brain donation program. METHODS: RAR parameters were assessed u...

K. Wolfova, C. White, N. M. Ghahjaverestan et al. · 0 citations

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