Occurrence of G allele at rs1800976 of ABCA1 gene in North Indian population (Haryana) confers increased susceptibility to atherosclerotic complications in diabetic individuals
Background Type 2 diabetes mellitus (T2DM), and coronary artery disease (CAD) are metabolically related lesions with dyslipidemia and the deficiency of cholesterol transportation. ABCA1 is a key gene in HDL metabolism, and its polymorphisms could act as cardiometabolic risk factors. Objective The study needed to examine how ABCA1 (rs1800977 and rs1800976) polymorphisms relate to T2DM and CAD, as well as to both in a North Indian cohort. Methods Case control study was done on 600 participants (controls, T2DM, CAD, T2DM+CAD; n=150 each). PCRRFLP was used to carry out genotyping. Statistical tests were chi-square tests, odds ratios (ORs), and haplotype analysis. Results There was no significant relationship with rs1800977. Conversely, the association between the two diseases (CAD and T2DM+CAD) with the association of a strong association with the frequency of G allele and the GG genotype was observed in the case of rs1800976 (OR=3.11 and 2.58, respectively; p<0.05). The high triglycerides and low HDL-C were associated with risk genotypes, and CG and TG were haplotypes of risk. Conclusion The polymorphism at the site (rs1800976) was greatly linked to higher forms of CAD and T2DM+CAD indicating that the site could serve as a genetic marker of cardiometabolic risk.