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P. Feng

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Open access Aug 2026

TOPORS Deficiency Impairs TET2 SUMOylation leading to aberrant m5C Hypermethylation that promotes adipogenic differentiation of mesenchymal stem cells in osteoporosis

Findings establish TOPORS as a key modulator of MSC fate and reveal a mechanistic link between protein SUMOylation and RNA m5C regulation in skeletal homeostasis, supporting a previously unrecognized regulatory role of TOPORS in osteoporosis.

Yi-Bin Zhang, Guangqi Tian, Yun-Hui Zhang et al. · 0 citations

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