Functional Mapping of the Trypanosoma cruzi Serinome by Fluorophosphonate Activity-Based Protein Profiling
An activity-based chemoproteomic map of the T. cruzi epimastigote serinome is reported by combining genome-informed in silico curation with whole-cell activity-based protein profiling (ABPP) using a panel of cell-permeable fluorophosphonate (FP)-alkyne probes to establish a fluorophosphonate-based chemoproteomic resour...