Casein Kinase 1 and CK2 as Therapeutic Targets in Cancer: Molecular Pharmacology, Toxicological Considerations, and Clinical Progress.
Casein kinase 1 (CK1) and casein kinase 2 (CK2) are highly conserved serine/threonine protein kinases that regulate multiple oncogenic signaling pathways involved in cancer progression, metastasis, and therapeutic resistance. Overexpression or dysregulation of CK1 and CK2 has been shown to contribute to the development...