Helicobacter pylori remains a major cause of gastric diseases, while increasing antimicrobial resistance highlights the need for novel therapeutic targets. Here, we developed a comprehensive computational target-prioritization framework integrating Rosetta Stone domain-fusion analysis, subtractive genomics, metabolic...
Manish Kumar, Hulikal Shivashankar Santosh kumar, B. Kumar et al.· ACS Omega· 0 citations
Special educators play a crucial role in supporting children with disabilities, yet social, institutional, and policy-related challenges shape their professional experiences. This study explored the lived experiences and perceived challenges of special educators in Tamil Nadu, India.
A qualitative descriptiv...
Harishma Ramesh, P. Gollapalli, R. Sivakumar et al.· Indian Journal of Community...· 0 citations
Endophytic fungi represent a valuable source of bioactive compounds with diverse pharmacological properties. In this study, we explored the antioxidant potential of secondary metabolites produced by Neopestalotiopsis clavispora (N.clavispora), an endophytic fungus isolated from Oroxylum indicum Kurz stem bark. N.clavis...
Sushma Swaroopa, Amshumala Bhoothakallu Lolajaksha, T. Gnanasekaran et al.· PLoS ONE· 0 citations
Findings suggest that Withaferin A and Obacunone could serve as promising therapeutic agents against H. pylori infections by disrupting quorum sensing and biofilm formation, thus addressing the challenge of antibiotic resistance in this pathogen.
Thejaswi Bhat, Manish Kumar, T. Gnanasekaran et al.· Biologia· 0 citations
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