P. Gomase

Formulation and Pharmacological Evaluation of Budesonide-Loaded Zinc-Crosslinked Chitosan Nanocomposite Spheroids in TNBS-Induced Colitis

Background: Inflammatory bowel disease, particularly ulcerative colitis, requires effective delivery of anti-inflammatory drugs to the inflamed colonic mucosa while minimizing systemic exposure. Budesonide is a potent topical corticosteroid; however, its low oral bioavailability and extensive first-pass metabolism limi...