Open access
Sep 2026
Identification of a C3b-specific nanobody that does not bind C3 and blocks alternative pathway convertases
C3b-specific nanobodies are developed by generating phage libraries from llamas immunized with purified and surface-bound C3b and Functionally, UNbC3b-1 inhibits complement activity in the alternative pathway (AP), likely by preventing association between substrate C3 and the AP C3 convertase (C3bBb).
Eva M. Struijf, B. Bardoel, Joanne E. van Keulen et al.
· bioRxiv · 0 citations