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Author

P. H. van der Graaf

2 papers indexed here

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Open access Sep 2026

From Biological Mechanisms to Causal Inference: Quantitative Systems Pharmacology and Causal Frameworks in Drug Development

Digital patients and in silico clinical trials offer new opportunities to advance pharmacological research, clinical development, and regulatory decision‐making by enabling the simulation of treatment effects prior to testing in patients. Among the most promising of these opportunities is the combined use of quantitati...

T. Klabunde, Ramon Hernandez, P. H. van der Graaf et al. · 0 citations
Review Open access Sep 2026

From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs

New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and...

Karen Rowland Yeo, P. H. van der Graaf · 0 citations

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