Development of an Injectable Thermosensitive Chitosan-Based Hydrogel for Localized Rutin Delivery Optimized Using Box-Behnken Design.
ObjectiveThe objective of the present study was to develop, optimize, and evaluate a chitosan (CS)-based hydrogel incorporating rutin for localized drug-delivery.SignificanceRutin, a naturally occurring flavonoid, possesses significant antioxidant, anti-inflammatory, and anticancer properties. However, its therapeutic...