Author

P. K. Mishra

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Open access Aug 2026

Polymer-specific nanoplastics trigger oxidative stress, inflammatory activation, and mitoepigenetic remodeling: in vitro and in silico evidence for MT-ND6-mediated mitochondrial complex I perturbation

Introduction Recent studies have detected nanoplastics (NPs) in human tissues and biological fluids, raising concerns regarding their potential effects on cellular homeostasis. Nevertheless, their effects on mitochondrial regulation and mitoepigenetic processes remain poorly understood. This work aimed to study the pol...

P. K. Mishra, Aneha K. Rajan, Apoorva Chouksey et al. · Frontiers in Toxicology · 0 citations

Open access Sep 2026

Fluorosphere-Assisted Nano-Biosensor for Detection of Circulating microRNAs in Non-Small Cell Lung Cancer

Non-small-cell lung cancer (NSCLC) diagnosis is challenged owing to the need for reliable, non-invasive biomarkers. Circulating cell-free microRNAs (ccf-miRNAs) are promising candidates, but their low levels and short sequences in blood complicate detection. In this study, a novel nano-hybrid fluorescent array was deve...

P. K. Mishra, R. Shandilya, Arpit Bhargava et al. · bioRxiv · 0 citations

Open access Aug 2026

Comparative Analysis of Ultrafine Particulate Matter, Black Carbon, and Polystyrene Nanoplastics Identifies Mitochondrial Stress Adaptation as a Conserved Mechanism of Immunotoxicity

It is found that mitochondrial stress response is a common mechanism underlying the toxicity of chemically different nanoparticles and have also revealed particle-specific stress-response dynamics responsible for the degree and persistence of cellular damage.

P. K. Mishra, Apoorva Chouksey, Aneha K. Rajan et al. · bioRxiv · 0 citations

Open access Jul 2026

Vitamin D mitigates Inflammatory Bone Loss in Postmenopausal Osteoporosis via modulating the Gut-Immune-Bone axis

It is demonstrated that vitamin D prevents bone loss through the coordinated regulation of immune and gut homeostasis, reconciling its apparent pro-resorptive effects in vitro with its overall anti-resorptive outcomes in vivo.

A. Bhardwaj, Leena Sapra, Tamanna Sharma et al. · bioRxiv · 0 citations