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Author

Patrycja Kaczara

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Open access Sep 2026

PFKFB3 and PFKFB4 inhibition modulates the response of metabolically plastic resistant melanoma cells to BRAF/MEK-targeted therapy

Despite the development of selective inhibitors targeting oncogenic BRAF mutations, melanoma therapy remains limited by acquired resistance driven by multiple mechanisms, including metabolic reprogramming. PFKFB isoenzymes regulate cellular adaptation to therapeutic stress and may therefore represent promising th...

S. Trojan, B. Ostrowska, P. Kaczara et al. · 0 citations
Open access Aug 2026

The dual PPAR-α/δ agonist elafibranor attenuates TGF-β1-induced cardiac fibrosis through redox-metabolic and bioenergetic reprogramming in human cardiac models

Elafibranor mitigates TGF-β1-driven cardiac fibrosis by suppressing fibroblast activation and ECM remodelling while promoting adaptive metabolic, redox, and bioenergetic responses, supporting balanced PPAR-α/δ activation as a potential therapeutic strategy for cardiac fibrosis.

M. Paw, L. Minder, A. Laimbacher et al. · 0 citations

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