Streptococcus pyogenes (Group A Streptococcus; GAS) is a World Health Organization (WHO) priority pathogen for vaccine development. GAS vaccine development and trials have been impeded by a poor understanding of GAS immunity, and to date no correlate of protection has been identified. The predominant focus of efforts h...
L. Mathew, Mohammad Ali, H. Townsley et al.· Frontiers in Cellular and In...· 0 citations
Adoptive T-cell therapy (ACT) has demonstrated marked clinical benefit in hematological malignancies but has limited efficacy against solid tumors. Cancer vaccines can improve ACT, but the mechanisms underlying this combination are poorly understood. Here, we combined ACT with chimpanzee adenovirus ChAdOx1 (ChAd) and m...
Vinnycius Pereira-Almeida, L. Garner, Sara Abdel Malak et al.· bioRxiv· 0 citations
In-cell ELISA is established as a scalable and reproducible approach for evaluating the expression and localization of HCV envelope glycoproteins, and support its use in the prioritization of candidate antigens for downstream studies.
Stavros Dimitriadis, M. Edmans, Nicole Frumento et al.· Microbiology spectrum· 0 citations
A new role for PRMT5 is defined in regulating and coordinating the interplay between the innate and adaptive immune response and it is found that RIs have a propensity to form double-stranded RNAs that contribute to the innate response.
Wiktoria Blaszczak, Wojciech Barczak, Chu-Yue Zhang et al.· EMBO Molecular Medicine· 1 citation
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