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Open access Sep 2026

Resistance to atrial fibrillation domestication and mitochondrial dysfunction in sheep: a potential key role of the TCA cycle and mitochondrial redox state

Background Atrial fibrillation (AF) often progresses from paroxysmal to more stable forms. It is well-recognized that patients vary in their AF progression, but the underlying mechanisms remain unclear. This work, performed in a sheep AF-model, aimed to identify atrial redox and energetic status differences between ani...

G. Caluori, S. Nattel, Benoît Pinson et al. · 0 citations
Open access Aug 2026

Pulmonary Vein Isolation Using Pulsed Field Ablation With vs Without Posterior Wall Isolation in Patients With Symptomatic Persistent Atrial Fibrillation: The PIFPAF-PFA Randomized Clinical Trial.

Importance Pulmonary vein isolation (PVI) is less effective in persistent than in paroxysmal atrial fibrillation (AF). Objective To determine whether adding posterior left atrial wall isolation (PWI) to pulsed field ablation (PFA)-based PVI reduces atrial tachyarrhythmia in patients with persistent AF. Design, Sett...

L. Roten, J. Maurhofer, P. Krisai et al. · 4 citations
Open access Sep 2026

Left atrial anatomy and atrial arrhythmia recurrence after pulsed-field ablation.

BACKGROUND The impact of left atrial (LA) anatomical features on atrial arrhythmia (AA) recurrence after pulsed-field (PF)-based pulmonary vein isolation (PVI) is unknown. This study aimed to assess LA anatomical features associated with long-term AA recurrence after PVI. METHODS We prospectively enrolled patients un...

M. Mutti, D. Spreen, Jonas Brügger et al. · 0 citations

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