Open access
Oct 2026
A histidine-mediated supramolecular mechanism links temperature and pH activation of the sperm channel CatSper.
The cation channel of sperm, CatSper, is a sperm-specific calcium channel essential for male fertility across metazoans. CatSper is activated by intracellular alkalinization, membrane depolarization, and elevated temperature, which together ensure maximal current generation. However, the structural mechanisms by which...
Billy Zhao, Shweta Bhagwat, Juan Ferreira et al.
· PLoS Biology · 0 citations