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P. Majumder

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Open access Aug 2026

A lipid fenestration-gated membrane depolarization mechanism expands the repertoire of CRISPR-mediated anti-phage defense strategies

This work characterize Chp1, a membrane-embedded CARF effector that assembles as a tetrameric pore harboring autoinhibitory lipid fenestrations that occlude the pore in the inactive state, and uncover a lipid-gated mechanism that expands the repertoire of CRISPR-mediated defense strategies.

P. Majumder, Heloise Carion, G. Stella et al. · 0 citations

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