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P. Maruff

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Open access Oct 2026

Targeting Pro-Inflammatory Interleukin-1 Beta Signaling to Modulate Neuroinflammatory Processes Associated with Cognitive Decline in Dementia with Lewy Bodies

Highlights What are the main findings? The oral p38α kinase inhibitor neflamapimod potently (EC50 ~6 nM) inhibits IL-1β-induced IL-6 and IL-8 production from human peripheral blood mononuclear cells. In clinical studies, neflamapimod reduces CSF levels of IL-6 and IL-8 in patients with early Alzheimer’s disease, and in...

John J. Alam, U. Germann, P. Maruff · 0 citations
Preprint Aug 2026

GenFAR: A generalized representation of brain structure, derived from 49,246 multi-cohort MRIs via deep learning

GenFAR, a modular deep learning framework that learns general, clinically informed features from brain MRIs, is introduced, showing that using the learned feature representation can substantially increase the sample efficiency of secondary deep learning training tasks and models, as well as improve their accuracy.

V. Bashyam, G. Erus, Jun-Hao Wen et al. · 0 citations

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