An illustrative multilevel, reciprocal pathophysiological framework that integrates evidence across brain network (macro), neurotransmitter (meso), and molecular and systemic scales that contribute to depression vulnerability in HD is presented.
Tamrin Barta, Y. Glikmann-Johnston, P. McColgan et al.· Neuroscience and Biobehavior...· 0 citations
Key biological mechanisms underlying TDP-43 pathology, emerging therapeutic strategies, and evolving approaches to clinical trial design and biomarker development are examined.
C. Estévez-Fraga, R. Álvarez-Velasco, T. Afroz et al.· Journal of Neurology· 1 citation
Using high-resolution qMRI, motor cortex subdivisions controlling the leg, hand, and face in humans and chimpanzees are compared and consistently higher myelin and iron content in the hand-knob in both species are found, suggesting an evolutionarily conserved role.
M. Chauvel, E. Kirilina, I. Lipp et al.· bioRxiv· 0 citations
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