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Open access Sep 2026

Clearance of p16‐positive cardiac cells improves age‐related cardiac remodeling in mice

Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearanc...

Mozhdeh Mehdizadeh, Martin Mackasey, Kimia Gharagozloo et al. · 0 citations
Open access Sep 2026

Resistance to atrial fibrillation domestication and mitochondrial dysfunction in sheep: a potential key role of the TCA cycle and mitochondrial redox state

Background Atrial fibrillation (AF) often progresses from paroxysmal to more stable forms. It is well-recognized that patients vary in their AF progression, but the underlying mechanisms remain unclear. This work, performed in a sheep AF-model, aimed to identify atrial redox and energetic status differences between ani...

G. Caluori, S. Nattel, Benoît Pinson et al. · 0 citations

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