Author

P. Nissen

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Open access Jul 2026

Mechanistic Insights into Autoinhibition of the Human Flippase ATP8B1

P4-ATPases are lipid flippases that maintain membrane phospholipid asymmetry by transporting specific phospholipids from the exoplasmic to the cytosolic leaflet, an essential process for membrane integrity, trafficking and signaling. Several P4-ATPases are tightly regulated by autoinhibitory N- and C-terminal extension...

Michelle Juknaviciute Laursen, Mathilde Roth, P. Nissen et al. · Journal of Membrane Biology · 0 citations

Review Open access Aug 2026

Dimerization in the SLC12 family: Structural and biochemical perspectives.

Solute carrier proteins (SLCs) are essential membrane protein transporters of small solutes. Among them, the SLC12 family is known to facilitate transport of ions. Members of the SLC12 family ensure cell homeostasis by co-transporting chloride alongside sodium and/or potassium across the plasma membrane. The majority o...

Alexandra Náplavová, P. Nissen, R. K. Flygaard · Journal of Structural Biolog... · 0 citations